Healthou-Recovery Food
  

NEWS




TEL:+1855 51 HELLO(43556)
ADD:237COTE VERTU,#33563
        ST-LAURENT,QUEBEC,CANADA,
        H4N1C8
        IN US BY VITALABS INC.
Healthou_The stress response to trauma and surgery
  1. J. P. Desborough

+Author Affiliations

  1. Department of Anaesthesia, Epsom General Hospital, Dorking Road, Epsom KT18 7EG, UK

Key words

Br J Anaesth 2000; 85: 109–17

The stress response is the name given to the hormonal and metabolic changes which follow injury or trauma. This is part of the systemic reaction to injury which encompasses a wide range of endocrinological, immunological and haematological effects (Table 1). The responses to surgery have been of interest to scientists for many years. In 1932, Cuthbertson described in detail the metabolic responses of four patients with lower limb injuries.10 He documented and quantified the time course of the changes. The terms ‘ebb’ and ‘flow’ were introduced to describe an initial decrease and subsequent increase in metabolic activity. The description of the ‘ebb’ phase was based partly on work in experimental animals and the estimations of increases in metabolic rate in the ‘flow’ phase were exaggerated. These descriptions have been perpetuated and are still quoted, but have been redefined29 and are perhaps not critical to an understanding of the actual changes which occur.

View this table:
Table 1

Systemic responses to surgery

 

After the early work on the stress response to accidental injury, attention turned to surgical trauma, and responses to most types of surgery were reported. Following on from this, the ability of anaesthetic agents and neural blockade to modify the endocrine and metabolic responses has been studied enthusiastically. Although it seems that the stress response developed to allow injured animals to survive by catabolizing their own stored body fuels, it has been argued that the response is unnecessary in current surgical practice. Strenuous efforts have been made to inhibit the stress responses to surgery and evaluate the outcome. In particular, the potential benefits of regional anaesthesia on surgical outcome are still under scrutiny. Over the past 10 yr, the role of cytokines in the response to surgery, and the interaction between the immunological and neuroendocrine …

from source:http://bja.oxfordjournals.org/content/85/1/109.short


CONTACT US | SECURITY AUTHENTICATION | SITE MAP
TEL:+1 855 51 HELLO(43556)
ADD:237COTE VERTU,#33563 ST-LAURENT,QUEBEC,CANADA,
H4N1C8 IN US BY VITALABS INC.

There statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose,treat,cure,or prevent any disease.