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Healthou_ACCELERATION OF WOUND HEALING IN MAN WITH ZINC SULPHATE GIVEN BY MOUTH
WalterJ. Pories, b,
JohnH. Henzel,, a, b,
CharlesG. Rob, c ,
WilliamH. Strain, c
- a OF THE SURGICAL SERVICES BRANCH , United Kingdom
- b UNITED STATES AIR FORCE HOSPITAL, WRIGHT-PATTERSON AIR FORCE BASE, OHIO, United Kingdom
- c SCHOOL OF MEDICINE AND DENTISTRY, UNIVERSITY OF ROCHESTER, N.Y., United Kingdom
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The need for zinc in the optimal healing of wounds was demonstrated by the acceleration of healing of granulating wounds caused by excision of pilonidal-sinus tracts in young, healthy airmen who were given zinc sulphate U.S.P., 220 mg. t.i.d. by mouth during the period of repair. The rate of healing was determined by measurements of the wound volumes and the number of days for complete repair. Ten randomly selected controls (mean age 25·0 years and wound volume 32·3 ml.) were matched against ten who were given the drug (mean age 24·6 years and wound volume 54·5 ml.). The days ±S.E. for healing averaged 80·1±13·7 in the controls and 45·8±2·6 (p<0·02) in the trial patients. Healing-rates (ml. per day ±S.E.) were 0·44±0·009 for controls and 1·25±0·30 (p<0·01), or nearly three times greater, in the treated group. Larger wounds healed 34·3 days or 43% sooner with orally administered zinc sulphate. Medication with zinc was carried out with due consideration for the rights and welfare of the volunteers; all patients were fully informed of the experimental nature of the trial and gave their consent freely. This was necessary because of the lack of clinical experience with zinc sulphate therapy in a dose of 220 mg. t.i.d. No toxic side-effects were observed over periods ranging from 43 to 61 days. Other clinical investigations disclosed no signs of toxicity even when zinc sulphate was continued for periods up to 22 months.
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